VON WILLEBRAND DISEASE
Described by Erik Adolf von Willebrand in 1926, it is a constitutional hemorrhagic disease, inherited in the autosomal mode. Considered initially as a thrombopathic disease, then as a prologation of the bleeding time associated to a defi cit in the factor VIII, today it is defi ned as an absence, di...
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| Main Authors: | , |
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| Format: | Book |
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Amaltea Medical Publishing House,
2009-11-01T00:00:00Z.
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| Summary: | Described by Erik Adolf von Willebrand in 1926, it is a constitutional hemorrhagic disease, inherited in the autosomal mode. Considered initially as a thrombopathic disease, then as a prologation of the bleeding time associated to a defi cit in the factor VIII, today it is defi ned as an absence, diminuation or a modifi cation of the von Willebrand factor, a glycoprotein sintetized by the endotheklial cell and the megariocyte. The incidence of the disease is around 2%, being the fi rst constitutionally hemorrhagic defi cit, in front of the hemophilias. In this article we present: phisiopathologic mechanisms of the disease, clinical signs, biologic diagnosis, classifi cation of von Willebrand disease, the differential diagnosis and treatment |
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| Item Description: | 10.37897/RJP.2009.4.8 1454-0398 2069-6175 |