Survivin and insulin-like growth factor-I: potential role in the pathogenesis of acne and post-acne scar
Backgrounds/objectives: Acne is an inflammatory disease of the pilosebaceous unit (PSU). The over-expression of survivin and insulin-like growth factor (IGF)-I in some fibrotic disorders suggests a possible implication in the pathogenesis of acne and or post-acne scar. We aimed to evaluate their pot...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
SAGE Publishing,
2019-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Backgrounds/objectives: Acne is an inflammatory disease of the pilosebaceous unit (PSU). The over-expression of survivin and insulin-like growth factor (IGF)-I in some fibrotic disorders suggests a possible implication in the pathogenesis of acne and or post-acne scar. We aimed to evaluate their potential role in pathogenesis in acne and post-acne scar. Methods: Serum survivin and IGF-I levels were estimated in 30 patients with acne and post-acne scar compared to 30 controls. Results: There was a statistically significant difference in survivin and IGF-I levels between controls and patients ( P < 0.05). However, there was no linear correlation between survivin and IGF-I. Conclusions: Survivin and IGF-I could have a possible role in the pathogenesis of active acne and in post-inflammatory acne scar. |
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| Item Description: | 2059-5131 10.1177/2059513118818031 |