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Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients

Background. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a "cytokine storm." Objective. The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers i...

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Main Authors: Maria Martinez-Urbistondo (Author), Alberto Mora-Vargas (Author), Esther Expósito-Palomo (Author), Raquel Castejón (Author), M. Jesús Citores (Author), Silvia Rosado (Author), Carmen de Mendoza (Author), Isolina Baños (Author), Ana Fernández-Cruz (Author), Lidia Daimiel (Author), Rodrigo San-Cristóbal (Author), Juan Antonio Vargas (Author), J. Alfredo Martinez (Author)
Format: Book
Published: Hindawi Limited, 2020-01-01T00:00:00Z.
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Summary:Background. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a "cytokine storm." Objective. The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients with coronavirus disease 2019 (COVID-19) on metabolic functions and accompanying clinical complications. Patients and Methods. A total of 165 patients diagnosed with COVID-19 pneumonia were examined for medical features and inflammatory markers such as blood IL-6, CRP, ferritin, LDH, neutrophil/lymphocyte index (NLI), D-Dimer, and Red Cell Distribution Width (RDW). Regression analyses concerning electronically collected medical data were adjusted by appropriate factors and confounding variables. Results. Plasma IL-6 determinations evidenced a consistent association with hospital stay days, Intensive Care Unit (ICU) admission, and mortality rates. Similar trends were found for other proinflammatory variables, where ferritin and NLI showed a remarkable value as surrogates. Hyperglycaemia and the Charlson Comorbidity Index Score were positively associated with the inflammatory response induced by the SARS-COV-2 infection. An unhealthy lifestyle such as smoking and alcoholic drinks consumption as well as excessive body adiposity influenced inflammatory-related outcomes in the screened patients. Conclusion. IL-6 together with other inflammatory biomarkers accompanied poor clinical and metabolic outcomes in COVID-19-infected patients. IL-6 may result in a suitable proxy to individually categorise patients in order to manage this infectious pandemic.
Item Description:0962-9351
1466-1861
10.1155/2020/2914275

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