Gene Targeting to the Cerebral Cortex Following Intranasal Administration of Polyplexes
Gene delivery to the cerebral cortex is challenging due to the blood brain barrier and the labile and macromolecular nature of DNA. Here we report gene delivery to the cortex using a glycol chitosan-DNA polyplex (GCP). In vitro, GCPs carrying a reporter plasmid DNA showed approximately 60% of the tr...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2022-05-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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