Neuroprotective effect of myoinositol on the cellular model of glutamate stress as a basis for the prevention of disorders of intrauterine development of the brain

• Main Authors: A. G. Kalacheva (Author), I. Yu. Torshin (Author), E. V. Stelmashuk (Author), E. E. Genrikhs (Author), O. P. Alexandrova (Author), L. G. Khaspekov (Author), O. A. Gromova (Author)
• Format: Book
• Published: LLC "Publisher OKI", 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2587-7836; 2686-8830; 10.24411/2587-7836-2018-10018.
• Keywords: нейроцитология; нейропротекция; нейротрофичность; нейропластичность; развитие мозга плода; цитидин-5-дифосфохолин; церебролизин; миоинозитол; neurocytology; neuroprotection; neurotrophines; neuroplasticity; brain development of the fetus; cytidine-5-diphosphocholine; cerebrolysin; myoinositol; Pharmacy and materia medica; RS1-441
• Source: Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 9-20 (2019)

Myoinositol is the basis for the synthesis of an important group of signal molecules, inositolphosphates, which mediate signal transmission from receptors of growth factors and neurotransmitters. Grants myo-Inositol promote the prevention of folate-resistant defects and neuroprotection of the fetal brain ischemia. The paper presents the results of a study of the effects of myoinositol on the growth of cerebellar neurons in culture under glutamate stress. It is shown that the effects of myoinositol on the survival of neurons (+17 %) exceed the effects of drugs that are usually used for neuroprotection (peptide extracts - + 10 %, choline preparations - no more than 3 %). Confirmed in the present work, a direct neuroprotective effect of myo-Inositol indicates the importance of the use of myo-Inositol during pregnancy with the aim of neuroprotection of the fetal brain.