Visible spectrophotometric determination of Cefadroxil using ethyl acetoacetate and formaldehyde reagents
Visible spectrophotometric method can be used to determine cefadroxil in the pharmaceutical dosage form. The reaction of cefadroxil with the condensation product of 2 mol ethyl acetoacetate and 1 mol formaldehyde in acidic condition (pH 3,5) at 45°C for 20 minutes yielded yellow product giving absor...
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Universitas Gadjah Mada,
2008-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_92a677f3406a4cdfb250e59edd83f037 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Ratna Asmah Susidarti |e author |
| 700 | 1 | 0 | |a Andrih Rianti |e author |
| 700 | 1 | 0 | |a Sudibyo Martono |e author |
| 245 | 0 | 0 | |a Visible spectrophotometric determination of Cefadroxil using ethyl acetoacetate and formaldehyde reagents |
| 260 | |b Universitas Gadjah Mada, |c 2008-01-01T00:00:00Z. | ||
| 500 | |a http://dx.doi.org/10.14499/indonesianjpharm0iss0pp41-47 | ||
| 500 | |a 2338-9427 | ||
| 500 | |a 2338-9486 | ||
| 520 | |a Visible spectrophotometric method can be used to determine cefadroxil in the pharmaceutical dosage form. The reaction of cefadroxil with the condensation product of 2 mol ethyl acetoacetate and 1 mol formaldehyde in acidic condition (pH 3,5) at 45°C for 20 minutes yielded yellow product giving absorption at 367 nm. The concentration of Cefadroxil was calculated by using standard curve Y = 1.6063 X + 0.1634, r = 0.9932, p = 0,001 and Vxo = 9,7%. Determination of cefadroxil capsule "X" (562.4 mg/capsule) showed that the concentration of cefadroxil observed is 490.5 mg/capsule (CV = 0.89%) and recovery value is 102.88% (CV = 0.67%). | ||
| 546 | |a EN | ||
| 690 | |a visible spectrophotometry | ||
| 690 | |a Cefadroxil | ||
| 690 | |a ethyl acetoacetate | ||
| 690 | |a formaldehyde | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Indonesian Journal of Pharmacy, Vol 19, Iss 1, Pp 41-47 (2008) | |
| 787 | 0 | |n http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/309 | |
| 787 | 0 | |n https://doaj.org/toc/2338-9427 | |
| 787 | 0 | |n https://doaj.org/toc/2338-9486 | |
| 856 | 4 | 1 | |u https://doaj.org/article/92a677f3406a4cdfb250e59edd83f037 |z Connect to this object online. |