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A Novel PARP Inhibitor YHP-836 For the Treatment of BRCA-Deficiency Cancers

PARP inhibitors have clinically demonstrated good antitumor activity in patients with BRCA mutations. Here, we described YHP-836, a novel PARP inhibitor, YHP-836 demonstrated excellent inhibitory activity for both PARP1 and PARP2 enzymes. It also allosterically regulated PARP1 and PARP2 via DNA trap...

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Main Authors: Tingting Du (Author), Zhihui Zhang (Author), Jie Zhou (Author), Li Sheng (Author), Haiping Yao (Author), Ming Ji (Author), Bailing Xu (Author), Xiaoguang Chen (Author)
Format: Book
Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
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