Differential CD4+ T-Cell Cytokine and Cytotoxic Responses Between Reactivation and Latent Phases of Herpes Zoster Infection

• Main Authors: Wenjie Jin (Author), Mike Fang (Author), Ismail Sayin (Author), Carson Smith (Author), Jeffrey Hunter (Author), Brian Richardson (Author), Jackelyn Golden (Author), Christopher Haley (Author), Kenneth Schmader (Author), Michael Betts (Author), Cheryl Cameron (Author), Stephen Tyring (Author), Mark Cameron (Author), David Canaday (Author)
• Format: Book
• Published: Case Western Reserve University, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: CD4+ T cells are a critical component of effective immune responses to varicella zoster virus (VZV), but their functional properties during the reactivation acute vs latent phase of infection remain poorly defined. Methods: Here we assessed the functional and transcriptomic properties of...