Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell anaemia treated with hydroxyurea

• Main Authors: Alano Martins Pedrosa (Author), Maritza Cavalcante Barbosa (Author), Thayna Nogueira dos Santos (Author), Luzia Kalyne Almeida Moreira Leal (Author), Amanda de Araújo Lopes (Author), Darcielle Bruna Dias Elias (Author), Greyce Luri Sasahara (Author), Bruno Coêlho Cavalcanti (Author), Romélia Pinheiro Gonçalves (Author)
• Format: Book
• Published: Universidade de São Paulo, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hydroxyurea (HU) is the most important advance in the treatment of sickle cell anaemia (SCA) for preventing complications and improving quality of life for patients. However, some aspects of treatment with HU remain unclear, including their effect on and potential toxicity to other blood cells such...