First Description of Colistin and Tigecycline-Resistant <i>Acinetobacter baumannii</i> Producing KPC-3 Carbapenemase in Portugal
Herein, we describe a case report of carbapenem-resistant <i>Acinetobacter baumannii</i> and <i>Klebsiella pneumoniae</i> isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular c...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2018-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Herein, we describe a case report of carbapenem-resistant <i>Acinetobacter baumannii</i> and <i>Klebsiella pneumoniae</i> isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes <i>bla</i><sub>KPC-3</sub>, <i>bla</i><sub>TEM-1</sub> and <i>bla</i><sub>SHV-1</sub> in both isolates. The KPC-3 <i>K. pneumoniae</i> isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the <i>A. baumannii</i> KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin. |
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| Item Description: | 2079-6382 10.3390/antibiotics7040096 |