Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst

• Главные авторы: Tiina Kelkka (Автор), Juha Petteri Laurila (Автор), Outi Sareila (Автор), Peter Olofsson (Автор), Mikko Olavi Laukkanen (Автор), Rikard Holmdahl (Автор)
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• Опубликовано: Hindawi Limited, 2012-01-01T00:00:00Z.
• Предметы: article
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Extracellular superoxide dismutase (SOD3), an enzyme mediating dismutation of superoxide into hydrogen peroxide, has been shown to reduce inflammation by inhibiting macrophage migration into injured tissues. In inflamed tissues, superoxide is produced by the phagocytic NOX2 complex, which consists o...