RAB18 is a key regulator of GalNAc-conjugated siRNA-induced silencing in Hep3B cells

• Main Authors: Jiamiao Lu (Author), Elissa Swearingen (Author), Miki Hardy (Author), Patrick Collins (Author), Bin Wu (Author), Eric Yuan (Author), Daniel Lu (Author), Chi-Ming Li (Author), Songli Wang (Author), Michael Ollmann (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small interfering RNA (siRNA) therapeutics have developed rapidly in recent years, despite the challenges associated with delivery of large, highly charged nucleic acids. Delivery of siRNA therapeutics to the liver has been established, with conjugation of siRNA to N-acetylgalactosamine (GalNAc) pro...