Antimicrobial Action and Reversal of Resistance in MRSA by Difluorobenzamide Derivatives Targeted at FtsZ

• Main Authors: Wern Chern Chai (Author), Jonathan J. Whittall (Author), Di Song (Author), Steven W. Polyak (Author), Abiodun D. Ogunniyi (Author), Yinhu Wang (Author), Fangchao Bi (Author), Shutao Ma (Author), Susan J. Semple (Author), Henrietta Venter (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bacterial cell division protein, FtsZ, has been identified as a target for antimicrobial development. Derivatives of 3-methoxybenzamide have shown promising activities as FtsZ inhibitors in Gram-positive bacteria. We sought to characterise the activity of five difluorobenzamide derivatives with...