The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis

• Main Authors: Tamer Rezk (Author), Janet A Gilbertson (Author), P Patrizia Mangione (Author), Dorota Rowczenio (Author), Nigel B Rendell (Author), Diana Canetti (Author), Helen J Lachmann (Author), Ashutosh D Wechalekar (Author), Paul Bass (Author), Philip N Hawkins (Author), Vittorio Bellotti (Author), Graham W Taylor (Author), Julian D Gillmore (Author)
• Format: Book
• Published: Wiley, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The tissue diagnosis of amyloidosis and confirmation of fibril protein type, which are crucial for clinical management, have traditionally relied on Congo red (CR) staining followed by immunohistochemistry (IHC) using fibril protein specific antibodies. However, amyloid IHC is qualitative,...