Identification of GRIN2D as a novel therapeutic target in pancreatic ductal adenocarcinoma

• Main Authors: Jiatong Wang (Author), Chi Hin Wong (Author), Yinxin Zhu (Author), Xiaoqiang Yao (Author), Kelvin K C Ng (Author), Chengzhi Zhou (Author), Ka Fai To (Author), Yangchao Chen (Author)
• Format: Book
• Published: BMC, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a dismal prognosis, and despite significant advances in our understanding of its genetic drivers, like KRAS, TP53, CDKN2A, and SMAD4, effective therapies remain limited. Here, we identified a new therapeutic ta...