Novel Mechanistic PBPK Model to Predict Renal Clearance in Varying Stages of CKD by Incorporating Tubular Adaptation and Dynamic Passive Reabsorption
Chronic kidney disease (CKD) has significant effects on renal clearance (CLr) of drugs. Physiologically‐based pharmacokinetic (PBPK) models have been used to predict CKD effects on transporter‐mediated renal active secretion and CLr for hydrophilic nonpermeable compounds. However, no studies have sh...
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| Format: | Book |
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Wiley,
2020-10-01T00:00:00Z.
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