Lymphoepithelioma-like carcinoma of the skin

• Asıl Yazarlar: Cristiano Claudino Oliveira (Yazar), Vinicius Cardoso Nóbrega (Yazar), Mariângela Esther Alencar Marques (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Sociedade Brasileira de Dermatologia, 2018-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.
• Notes: 0365-0596; 10.1590/abd1806-4841.20187205
• Keywords: Immunohistochemistry; Pathology; Skin neoplasms; Dermatology; RL1-803
• Source: Anais Brasileiros de Dermatologia, Vol 93, Iss 2, Pp 256-258 (2018)

Abstract: Primary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate. Immunohistochemistry revealed cytokeratin-positive cells (AE1/AE3) and p63 protein, indicating epithelial histogenesis and squamous differentiation. A negative Epstein-Barr virus test result was achieved by immunohistochemistry. Primary lymphoepithelioma-like carcinoma of the skin is a differential diagnosis of lesions with prominent inflammatory infiltrates.