Early VGLUT1-specific parallel fiber synaptic deficits and dysregulated cerebellar circuit in the KIKO mouse model of Friedreich ataxia

• Main Authors: Hong Lin (Author), Jordi Magrane (Author), Elisia M. Clark (Author), Sarah M. Halawani (Author), Nathan Warren (Author), Amy Rattelle (Author), David R. Lynch (Author)
• Format: Book
• Published: The Company of Biologists, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder with progressive ataxia that affects both the peripheral and central nervous system (CNS). While later CNS neuropathology involves loss of large principal neurons and glutamatergic and GABAergic synaptic terminals in the c...