Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions
Hidradenitis suppurativa (HS) is an inflammatory disease of the skin with a chronic, relapsing-remitting course. The pathogenesis of the disease is poorly understood and involves multiple factors, including genetics, environment, host-microbe interactions, and immune dysregulation. In particular, th...
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| Main Authors: | , , , , |
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| Format: | Book |
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Elsevier,
2021-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Hidradenitis suppurativa (HS) is an inflammatory disease of the skin with a chronic, relapsing-remitting course. The pathogenesis of the disease is poorly understood and involves multiple factors, including genetics, environment, host-microbe interactions, and immune dysregulation. In particular, the composition of the cutaneous microbiome shifts as the disease progresses, although it is unclear whether this is a primary or secondary process. Trials with immunomodulatory therapy elucidate the role of specific immune pathways and cytokine signaling in disease mechanism, such as TNF-α, IL-1β, IL-12, IL-17, IL-23, and complement. Future studies should continue examining the causes of and contributing factors to microbial changes and immune dysregulation in HS pathogenesis. |
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| Item Description: | 2667-0267 10.1016/j.xjidi.2021.100001 |