Therapeutic drug monitoring of phenytoin and valproic acid in critically ill patients at Windhoek Central Hospital, Namibia

• Үндсэн зохиолчид: Bonifasius S. Singu (Зохиогч), Helen Morrison (Зохиогч), Lydia Irengeya (Зохиогч), Roger K. Verbeeck (Зохиогч)
• Формат: Ном
• Хэвлэсэн: AOSIS, 2022-07-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Background: Phenytoin and valproic acid, anticonvulsants, have a low therapeutic index and are highly plasma protein bound, mainly to albumin. Hypoalbuminaemia is common in critically ill patients and increases the unbound drug concentration. Thus, monitoring unbound rather than total plasma drug co...