Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient

• Main Authors: Fernanda Cristina A Maranhão (Author), Douglas L. H Fonseca (Author), Graciella S. A Santos (Author), Luisa Andrea V Fonseca (Author), Eduardo José L Santos (Author), Denise Maria W Silva (Author)
• Format: Book
• Published: Sociedade Brasileira de Patologia Clínica, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

ABSTRACT Cryptococcosis is caused by yeasts of the Cryptococcus neoformans/C. gattii complex, presenting cutaneous, respiratory and disseminated forms. A 44-year-old immunocompetent male with facial lesion and latent pneumonia was hospitalized and misdiagnosed with paracoccidioidomycosis. Computerized tomography scans showed pulmonary and neurological involvement, and cultures/China ink, cryptococcal antigen test and restriction fragment length polymorphism of urease gene (URA5-RFLP) confirmed C. neoformans genotype VNI. Hemoculture indicated ampicillin-resistant Klebsiella pneumoniae (healthcare-associated infection). Fluconazole was administered, but after resistance detection, amphotericin B was chosen (cumulative dose/1500 mg). The patient was discharged with clinical remission (75 days) and amphotericin for one year (maintenance phase).

Item Description

1678-4774
10.5935/1676-2444.20200017