Effect of Phenolics from <i>Aeonium arboreum</i> on Alpha Glucosidase, Pancreatic Lipase, and Oxidative Stress; a Bio-Guided Approach

• Main Authors: Marwah M. Alfeqy (Author), Seham S. El-Hawary (Author), Ali M. El-Halawany (Author), Mohamed A. Rabeh (Author), Saad A. Alshehri (Author), Aya M. Serry (Author), Heba A. Fahmy (Author), Marwa. I. Ezzat (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Metabolic syndrome (MetS) is a global issue affecting over a billion people, raising the risk of diabetes, cardiovascular disorders, and other ailments. It is often characterized by hypertension, dyslipidemia and/or obesity, and hyperglycemia. Chemical investigation of <i>Aeonium arboreum</i> (L.) Webb & Berthel led to the isolation of six compounds, viz. β-sitosterol, β-sitosterol glucoside, myricetin galactoside, quercetin rhamnoside, kaempferol rhamnoside, and myricetin glucoside. Interestingly, <i>A. arboreum</i>'s dichloromethane (DCM), 100 and 50% MeOH Diaion fractions and the isolated compound (quercetin-3-rhamnoside) revealed potent α-glucosidase inhibitory activity, especially 50% Diaion fraction. In addition, they also showed very potent antioxidant potential, especially the polar fractions, using DPPH, ABTS, FRAP, ORAC, and metal chelation assays. Notably, the 50% Diaion fraction had the highest antioxidant potential using DPPH and ORAC assays, while the 100% Diaion fraction and quercetin-3-rhamnoside showed the highest activity using ABTS, FRAP, and metal chelation assays. Also, quercetin-3-rhamnoside showed a good docking score of −5.82 kcal/mol in comparison to acarbose. In addition, molecular dynamic stimulation studies illustrated high stability of compound binding to pocket of protein. Such potent activities present <i>A. arboreum</i> as a complementary safe approach for the management of diabetes mellitus as well as MetS.

Item Description

10.3390/pharmaceutics15112541
1999-4923