Changes in Blood Viscosity With Synthetic Protease Inhibitors
We examined the effects on whole blood viscosity and coagulation time of various dosages of the synthetic low-molecular protease inhibitors gabexate mesilate and nafamostat mesilate with an oscillation-type viscometer. When either agent was added, blood viscosity decreased dose-dependently along a s...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Elsevier,
2003-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | We examined the effects on whole blood viscosity and coagulation time of various dosages of the synthetic low-molecular protease inhibitors gabexate mesilate and nafamostat mesilate with an oscillation-type viscometer. When either agent was added, blood viscosity decreased dose-dependently along a sigmoid-like curve. Furthermore, coagulation time was shorter with gabexate mesilate than with nafamostat mesilate owing to the differences of half-life in human blood. Thrombin generation, which results from the activation of coagulation factors, is inhibited by synthetic protease inhibitors and subsequently decreases blood viscosity dose-dependently. |
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| Item Description: | 1347-8613 10.1254/S1347-8613(19)32717-3 |