Molecular Neuroimaging of the Dopamine Transporter as a Patient Enrichment Biomarker for Clinical Trials for Early Parkinson's Disease

• Main Authors: Klaus Romero (Author), Daniela Conrado (Author), Jackson Burton (Author), Timothy Nicholas (Author), Vikram Sinha (Author), Sreeraj Macha (Author), Malidi Ahamadi (Author), Jesse Cedarbaum (Author), John Seibyl (Author), Kenneth Marek (Author), Peter Basseches (Author), Derek Hill (Author), Ed Somer (Author), Jill Gallagher (Author), David T. Dexter (Author), Arthur Roach (Author), Diane Stephenson (Author), for the Critical Path for Parkinson's (CPP) (Author), the Parkinson's Progression Markers Initiative (PPMI) (Author)
• Format: Book
• Published: Wiley, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

The Critical Path for Parkinson's (CPP) Imaging Biomarker and Modeling and Simulation working groups aimed to achieve qualification opinion by the European Medicines Agency (EMA) Committee for Medical Products for Human Use (CHMP) for the use of baseline dopamine transporter neuroimaging for patient selection in early Parkinson's disease clinical trials. This paper describes the regulatory science strategy to achieve this goal. CPP is an international consortium of three Parkinson's charities and nine pharmaceutical partners, coordinated by the Critical Path Institute.

Item Description

1752-8062
1752-8054
10.1111/cts.12619