(1 →3)- β -D-Glucan and endotoxin modulate immune response to inhaled allergen
Exposure to dust may involve co-exposure to agents which are allergens, together with those which are pro-inflamm atory. To study the effects of such a coexposure, the humoral and inflammatory responses were studied in guinea pigs inhaling the T-cell dependent antigen ovalbumin (OVA) and the inflamm...
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| Main Authors: | , |
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| Format: | Book |
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Hindawi Limited,
1998-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Exposure to dust may involve co-exposure to agents which are allergens, together with those which are pro-inflamm atory. To study the effects of such a coexposure, the humoral and inflammatory responses were studied in guinea pigs inhaling the T-cell dependent antigen ovalbumin (OVA) and the inflammatory agents (1→3)-β -D-glucan and lipopolysaccharide (LPS). The effects were evaluated as inflammatory cells in the lung and serum antibodies to OVA. LPS caused a stimulation of the OVA-induced antibody production which was abolished by simultaneous exposure to (1→3)-β-D-glucan. An increase of eosinophils after OVA exposure was decreased by coexposure to (1→3)-β-D-glucan. The results demonstrate a complex interaction between adaptive and innate immune mechanisms in the lung, determined by exposure to common contaminants in airborne dust. |
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| Item Description: | 0962-9351 1466-1861 10.1080/09629359891252 |