Mortality and failure among tuberculosis patients who did not complete treatment in Vietnam: a cohort study

<p>Abstract</p> <p>Background</p> <p>Tuberculosis treatment failure and death rates are low in the Western Pacific Region, including Vietnam. However, failure or death may also occur among patients who did not complete treatment, i.e. reported as default or transfer-out...

Full description

Saved in:
Bibliographic Details
Main Authors: Van Le N (Author), Sy Dinh N (Author), Duong Bui D (Author), Huong Nguyen T (Author), Vree Marleen (Author), Co Nguyen V (Author), Cobelens Frank GJ (Author), Borgdorff Martien W (Author)
Format: Book
Published: BMC, 2007-07-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_950b8daad82746e0b75c46c7a18ed1d8
042 |a dc 
100 1 0 |a Van Le N  |e author 
700 1 0 |a Sy Dinh N  |e author 
700 1 0 |a Duong Bui D  |e author 
700 1 0 |a Huong Nguyen T  |e author 
700 1 0 |a Vree Marleen  |e author 
700 1 0 |a Co Nguyen V  |e author 
700 1 0 |a Cobelens Frank GJ  |e author 
700 1 0 |a Borgdorff Martien W  |e author 
245 0 0 |a Mortality and failure among tuberculosis patients who did not complete treatment in Vietnam: a cohort study 
260 |b BMC,   |c 2007-07-01T00:00:00Z. 
500 |a 10.1186/1471-2458-7-134 
500 |a 1471-2458 
520 |a <p>Abstract</p> <p>Background</p> <p>Tuberculosis treatment failure and death rates are low in the Western Pacific Region, including Vietnam. However, failure or death may also occur among patients who did not complete treatment, i.e. reported as default or transfer-out. We aimed to assess the proportion failures and deaths among new smear-positive pulmonary tuberculosis patients with reported default or transfer-out.</p> <p>Treatment outcomes rates were 1.4% default, 3.0% transfer-out, 0.4% failure and 2.6% death in northern Vietnam in 2003.</p> <p>Methods</p> <p>Tuberculosis patients in 32 randomly selected district tuberculosis units in northern Vietnam were followed up 1 to 3 years after treatment initiation for survival, recent treatment history and bacteriologically confirmed tuberculosis.</p> <p>Results</p> <p>Included were 85 transferred patients and 42 who defaulted. No information was available of 41 (32%), 28 (22%) had died. Fifty-eight were available for follow-up (46%); all had sputum smear results. Tuberculosis was recorded in 11 (13%), including 6 (7%) with positive sputum smears, 3 (3%) with negative smears but positive culture and 2 (2%) who had started re-treatment for bacteriologically confirmed tuberculosis. Fifteen (17%, 95%CI 10-27%) had died within 8 months after treatment initiation. Of 86 patients with known study outcomes, 39 (45%, 95%CI 35-56%) had died or had bacteriologically confirmed tuberculosis. This was recorded for 29/53 (55%, 95%CI 40-68%) transferred patients and 10/33 (30%, 95%CI 16-49%) patients who defaulted.</p> <p>Conclusion</p> <p>The total failure and death rates are 0.6% and 0.8% higher than based on routine reporting in northern Vietnam. Although this was a large proportion of treatment failures and deaths, failure and death rates were low. Defaulting and transfer carry a high risk of failure and in particular death.</p> 
546 |a EN 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n BMC Public Health, Vol 7, Iss 1, p 134 (2007) 
787 0 |n http://www.biomedcentral.com/1471-2458/7/134 
787 0 |n https://doaj.org/toc/1471-2458 
856 4 1 |u https://doaj.org/article/950b8daad82746e0b75c46c7a18ed1d8  |z Connect to this object online.