Case Report: Lomustine overdose in a 15-year-old, healthy adolescent-a prescription failure

Lomustine is an oral chemotherapy drug commonly used in pediatric neuro-oncology. We report on a 15-year-old formerly healthy boy, who was erroneously prescribed lomustine instead of an antibiotic for tonsillitis. He subsequently suffered from prolonged bone marrow aplasia with secondary fever in ne...

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Bibliographic Details
Main Authors: Ole Lindner (Author), Natalia Rotari (Author), Ayami Yoshimi (Author), Charlotte M. Niemeyer (Author), Simone Hettmer (Author)
Format: Book
Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Ole Lindner  |e author 
700 1 0 |a Natalia Rotari  |e author 
700 1 0 |a Ayami Yoshimi  |e author 
700 1 0 |a Charlotte M. Niemeyer  |e author 
700 1 0 |a Simone Hettmer  |e author 
245 0 0 |a Case Report: Lomustine overdose in a 15-year-old, healthy adolescent-a prescription failure 
260 |b Frontiers Media S.A.,   |c 2024-02-01T00:00:00Z. 
500 |a 2296-2360 
500 |a 10.3389/fped.2024.1339597 
520 |a Lomustine is an oral chemotherapy drug commonly used in pediatric neuro-oncology. We report on a 15-year-old formerly healthy boy, who was erroneously prescribed lomustine instead of an antibiotic for tonsillitis. He subsequently suffered from prolonged bone marrow aplasia with secondary fever in neutropenia and ubiquitous bleeding. Bone marrow regeneration started approximately 7 weeks after lomustine intake. No other permanent organ damage has been detected thus far. Oral chemotherapeutic drugs should only be prescribed by experts and dispensed in the smallest possible pack size. 
546 |a EN 
690 |a lomustine 
690 |a chemotherapeutic 
690 |a overdose 
690 |a pediatric 
690 |a oncology 
690 |a adverse events 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Frontiers in Pediatrics, Vol 12 (2024) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fped.2024.1339597/full 
787 0 |n https://doaj.org/toc/2296-2360 
856 4 1 |u https://doaj.org/article/950f2a5280a747ea9544200c3b9641a0  |z Connect to this object online.