Case report: Clinical management of recurrent small cell lung cancer transformation complicated with lung cancer-induced acute pancreatitis after lung adenocarcinoma surgery

In the diagnosis and treatment of non-small cell lung cancer (NSCLC), the histological type may change from lung adenocarcinoma to lung squamous cell cancer or small cell lung cancer (SCLC). Pancreatic metastasis is extremely rare in advanced lung cancer, and pancreatitis characterized by lung cance...

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Main Authors: Suyun Zhang (Author), Ningjing Guo (Author), Qianyuan Zhang (Author), Yao Wang (Author), Sheng Yang (Author), Xiangqi Chen (Author)
Format: Book
Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Suyun Zhang  |e author 
700 1 0 |a Ningjing Guo  |e author 
700 1 0 |a Qianyuan Zhang  |e author 
700 1 0 |a Yao Wang  |e author 
700 1 0 |a Sheng Yang  |e author 
700 1 0 |a Xiangqi Chen  |e author 
245 0 0 |a Case report: Clinical management of recurrent small cell lung cancer transformation complicated with lung cancer-induced acute pancreatitis after lung adenocarcinoma surgery 
260 |b Frontiers Media S.A.,   |c 2023-10-01T00:00:00Z. 
500 |a 1663-9812 
500 |a 10.3389/fphar.2023.1259221 
520 |a In the diagnosis and treatment of non-small cell lung cancer (NSCLC), the histological type may change from lung adenocarcinoma to lung squamous cell cancer or small cell lung cancer (SCLC). Pancreatic metastasis is extremely rare in advanced lung cancer, and pancreatitis characterized by lung cancer metastasis-induced acute pancreatitis (MIAP) is more rare. This paper reports in detail the clinical diagnosis and treatment of a female patient with lung adenocarcinoma who relapsed after radical surgery and progressed after multiple treatments. A second pathological biopsy revealed SCLC transformation, and the patient developed pancreatic metastasis and lung cancer MIAP during follow-up treatment. This paper mainly suggests that clinicians should pay attention to the possibility of pathological type transformation in the progression of advanced NSCLC, closely observe the dynamic changes of tumor markers and pay attention to the re-biopsy pathological analysis. In addition, it provides clinical experience and scientific reference for the discovery, diagnosis and treatment of transforming SCLC and lung cancer MIAP. 
546 |a EN 
690 |a lung adenocarcinoma 
690 |a small cell lung cancer 
690 |a acute pancreatitis 
690 |a pathological type transformation 
690 |a case report 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Frontiers in Pharmacology, Vol 14 (2023) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fphar.2023.1259221/full 
787 0 |n https://doaj.org/toc/1663-9812 
856 4 1 |u https://doaj.org/article/953c93e383be4c53bce1abccc61d00b6  |z Connect to this object online.