Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies

• প্রধান লেখক: Martin J. Scott (লেখক), Amanda Jowett (লেখক), Martin Orecchia (লেখক), Peter Ertl (লেখক), Larissa Ouro-Gnao (লেখক), Julia Ticehurst (লেখক), David Gower (লেখক), John Yates (লেখক), Katie Poulton (লেখক), Carol Harris (লেখক), Michael J. Mullin (লেখক), Kathrine J. Smith (লেখক), Alan P. Lewis (লেখক), Nick Barton (লেখক), Michael L. Washburn (লেখক), Ruud de Wildt (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Complex cellular targets such as G protein-coupled receptors (GPCRs), ion channels, and other multi-transmembrane proteins represent a significant challenge for therapeutic antibody discovery, primarily because of poor stability of the target protein upon extraction from cell membranes. To assess wh...