Cpd-42 protects against calcium oxalate nephrocalcinosis-induced renal injury and inflammation by targeting RIPK3-mediated necroptosis

• Main Authors: Bingbing Hou (Author), Mingming Liu (Author), Yang Chen (Author), Weijian Ni (Author), Xiaoguo Suo (Author), Yuexian Xu (Author), Qiushi He (Author), Xiaoming Meng (Author), Zongyao Hao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calcium oxalate (CaOx) crystals, as the predominant component of human kidney stones, can trigger excessive cell death and inflammation of renal tubular epithelial cells, involved in the pathogenesis of nephrocalcinosis. Necroptosis mediated by receptor-interacting protein kinase 3 (RIPK3) serves a...