Ferroptosis and Its Potential Role in the Nervous System Diseases

• Main Authors: Zhou Y (Author), Lin W (Author), Rao T (Author), Zheng J (Author), Zhang T (Author), Zhang M (Author), Lin Z (Author)
• Format: Book
• Published: Dove Medical Press, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Yiyang Zhou,1,* Wei Lin,1,* Tian Rao,1 Jinyu Zheng,2 Tianlei Zhang,1 Min Zhang,1 Zhenlang Lin1 1Department of Pediatrics, The Second School of Medicine, Taizhou Women and Children's Hospital of Wenzhou Medical University, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China; 2Department of Clinical Medicine, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China*These authors contributed equally to this workCorrespondence: Zhenlang Lin, Email [e-mail]: Ferroptosis is a novel regulated cell death characterized by metabolic disorders and iron-dependent oxidative destruction of the lipid bilayer. It is primarily caused by the imbalance of oxidation and anti-oxidation in the body and is precisely regulated by numerous factors and pathways inside and outside the cell. Recent studies have indicated that ferroptosis plays a vital role in the pathophysiological process of multiple systems of the body including the nervous system. Ferroptosis may be closely linked to the occurrence and development of neurodegenerative diseases, strokes, and brain tumors. It may also be involved in the development, maturation, and aging of the nervous system. Therefore, this study aims to investigate ferroptosis's occurrence and regulatory mechanism and summarize its research progress in the pathogenesis and treatment of neurological diseases. This would allow for novel ideas for basic and clinical research of neurological diseases.Keywords: ferroptosis, iron, lipid peroxidation, molecular mechanism, neurodevelopment, neurological diseases

Item Description

1178-7031