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Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension

Abstract Background A dysfunction of NADH dehydrogenase, the mitochondrial Complex I (CI), associated with the development of left ventricular hypertrophy (LVH) in previous experimental studies. A deficiency of Ndufc2 (subunit of CI) impairs CI activity causing severe mitochondrial dysfunction. The...

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Main Authors: Giovanna Gallo (Author), Maurizio Forte (Author), Maria Cotugno (Author), Simona Marchitti (Author), Rosita Stanzione (Author), Giuliano Tocci (Author), Franca Bianchi (Author), Silvia Palmerio (Author), Mariarosaria Scioli (Author), Giacomo Frati (Author), Sebastiano Sciarretta (Author), Emanuele Barbato (Author), Massimo Volpe (Author), Speranza Rubattu (Author)
Format: Book
Published: BMC, 2023-08-01T00:00:00Z.
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