Clinical Assessment of Breast Cancer Resistance Protein (BCRP)-Mediated Drug-Drug Interactions of Sepiapterin with Curcumin and Rosuvastatin in Healthy Volunteers

• Main Authors: Lan Gao (Author), Diksha Kaushik (Author), Kimberly Ingalls (Author), Sarah Milner (Author), Neil Smith (Author), Ronald Kong (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background and Objective Sepiapterin, also known as PTC923 and CNSA-001, is a synthetic form of endogenous sepiapterin being developed as a novel oral treatment for phenylketonuria. Sepiapterin is a natural precursor of tetrahydrobiopterin (BH4) and, when orally administered, is converted t...