USP15 regulates radiation-induced DNA damage and intestinal injury through K48-linked deubiquitination and stabilisation of ATM

• Main Authors: Ruiqiu Zhu (Author), Mingyue Li (Author), Difan Wang (Author), Chengzhi Liu (Author), Liwei Xie (Author), Yinyin Yang (Author), Xuhao Gu (Author), Kui Zhao (Author), Ye Tian (Author), Shang Cai (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Radiation-induced intestinal injury (RIII) interrupts the scheduled processes of abdominal and pelvic radiotherapy (RT) and compromises the quality of life of cancer survivors. However, the specific regulators and mechanisms underlying the effects of RIII remain unknown. The biol...