Intradermal Injection of Oxytocin Aggravates Chloroquine-Induced Itch Responses via Activating the Vasopressin-1a Receptor/Nitric Oxide Pathway in Mice

• Main Authors: Rulong Li (Author), Hua Sun (Author), Haotian Zheng (Author), Zhihua Zong (Author), Shengnan Li (Author), Tingting Meng (Author), Jing Li (Author), Yunfang Liu (Author), Chao Wang (Author), Jingxin Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxytocin (OT), a hormone synthesized within the paraventricular nucleus and supraoptic nucleus of the hypothalamus, when given intracerebroventricularly, induces strong scratching behaviors. However, it is not clear whether intradermal injection (ID) of OT elicits itch sensation. Herein, we found th...