Synthesis and Biological Evaluation of Some New 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1<i>H</i>)-ones and 3-Aryl-2-(benzylthio)quinazolin-4(3<i>H</i>)-ones as Antioxidants; COX-2, LDHA, α-Glucosidase and α-Amylase Inhibitors; and Anti-Colon Carcinoma and Apoptosis-Inducing Agents

• Main Authors: Nahed Nasser Eid El-Sayed (Author), Taghreed M. Al-Otaibi (Author), Assem Barakat (Author), Zainab M. Almarhoon (Author), Mohd. Zaheen Hassan (Author), Maha I. Al-Zaben (Author), Najeh Krayem (Author), Vijay H. Masand (Author), Abir Ben Bacha (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress, COX-2, LDHA and hyperglycemia are interlinked contributing pathways in the etiology, progression and metastasis of colon cancer. Additionally, dysregulated apoptosis in cells with genetic alternations leads to their progression in malignant transformation. Therefore, quinazolinones...