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A High-Sodium Diet in Streptozotocin-Induced Diabetic Rats Impairs Endothelium-Derived Hyperpolarizing Factor-Mediated Vasodilation

We examined endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of mesenteric arteries in high-sodium loaded streptozotocin (STZ)-induced diabetic rats. The study shows that acetylcholine (ACh)-induced, EDHF-mediated relaxation is relatively maintained in STZ-induced diabetic rats,...

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Main Authors: Yasutoshi Hirabara (Author), Mina Araki (Author), Mio Fukuda (Author), Shiori Katafuchi (Author), Kenji Honda (Author), Ryo Saito (Author), Yukio Takano (Author)
Format: Book
Published: Elsevier, 2007-01-01T00:00:00Z.
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Summary:We examined endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of mesenteric arteries in high-sodium loaded streptozotocin (STZ)-induced diabetic rats. The study shows that acetylcholine (ACh)-induced, EDHF-mediated relaxation is relatively maintained in STZ-induced diabetic rats, but after a high-sodium diet was given, the function was significantly impaired in STZ-induced diabetic rats. Keywords:: diabetes, mesenteric artery, endothelium-derived hyperpolarizing factor, (EDHF)-mediated relaxation
Item Description:1347-8613
10.1254/jphs.SC0070091

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