The biased apelin receptor agonist, MM07, reverses Sugen/hypoxia-induced pulmonary arterial hypertension as effectively as the endothelin antagonist macitentan

• Asıl Yazarlar: Thomas L. Williams (Yazar), Duuamene Nyimanu (Yazar), Rhoda E. Kuc (Yazar), Richard Foster (Yazar), Robert C. Glen (Yazar), Janet J. Maguire (Yazar), Anthony P. Davenport (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Introduction: Pulmonary arterial hypertension (PAH) is characterised by endothelial dysfunction and pathological vascular remodelling, resulting in the occlusion of pulmonary arteries and arterioles, right ventricular hypertrophy, and eventually fatal heart failure. Targeting the apelin receptor wit...