Validation of automated positive cell and region detection of immunohistochemically stained laryngeal tumor tissue using digital image analysis

• Үндсэн зохиолчид: Hilde J.G. Smits (Зохиогч), Justin E. Swartz (Зохиогч), Marielle E.P. Philippens (Зохиогч), Remco de Bree (Зохиогч), Johannes H.A.M. Kaanders (Зохиогч), Sjors A. Koppes (Зохиогч), Gerben E. Breimer (Зохиогч), Stefan M. Willems (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2023-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Objectives: This study aimed to validate a digital image analysis (DIA) workflow for automatic positive cell detection and positive region delineation for immunohistochemical hypoxia markers with a nuclear (hypoxia-inducible factor 1α [HIF-1α]) and a cytoplasmic (pimonidazole [PIMO]) staining patter...