<i>Mangifera indica</i> 'Namdokmai' Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a <i>Drosophila</i> Model of Alzheimer's Amyloidosis

• Main Authors: Piya Temviriyanukul (Author), Suwapat Kittibunchakul (Author), Piyapat Trisonthi (Author), Thanit Kunkeaw (Author), Woorawee Inthachat (Author), Dalad Siriwan (Author), Uthaiwan Suttisansanee (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Alzheimer's disease (AD) is a progressive neurological illness with few effective treatments. Thus, ameliorating the effects of AD using natural products has attracted global attention with promising efficacy and safety. In this study, ten tropical fruits including <i>Ananas comosus</i> 'Phulae', <i>Ananas comosus</i> 'Pattavia', <i>Carica papaya</i> 'Khaekdum', <i>Carica papaya</i> 'Khaeknuan', <i>Durio zibethinus</i> 'Monthong', <i>Durio zibethinus</i> 'Chanee', <i>Psidium guajava</i> 'Kimju', <i>Psidium guajava</i> 'Keenok', <i>Mangifera indica</i> 'Kaew' and <i>Mangifera indica</i> 'Namdokmai' were screened for their inhibitory activities against the key enzymes, cholinesterases and β-secretase (BACE-1), involved in AD pathogenesis. The top three fruit extracts with promising in vitro anti-AD activities were further investigated using rat pheochromocytoma PC-12 neuronal cell line and <i>Drosophila</i> AD model. Data showed that <i>M. indica</i> 'Kaew', <i>M. indica</i> 'Namdokmai' and <i>P. guajava</i> 'Kimju' reduced Aβ_1-42-mediated neurotoxicity by promoting glutathione-dependent enzymes, while <i>M. indica</i> 'Namdokmai' limited Aβ_1-42 peptide formation via BACE-1 inhibition and amended locomotory behavior of the <i>Drosophila</i> AD model. Results indicated the potential anti-AD properties of tropical fruits, particularly <i>M. indica</i> 'Namdokmai' in the prevention of Aβ_1-42-mediated neurotoxicity and as a BACE-1 blocker.

Item Description

10.3390/ph15050591
1424-8247