Oxidative Stress in Liver Pathophysiology and Disease
The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which not only arise during metabolic functions but also during the biotransformation of xenobiotics. The disruption of redox balance causes oxidative stress, which affects liver function, modulates inflammatory pat...
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| Format: | Book |
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MDPI AG,
2023-08-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_96f861c67ec04be88a02d1f829e76ab3 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Abdolamir Allameh |e author |
| 700 | 1 | 0 | |a Reyhaneh Niayesh-Mehr |e author |
| 700 | 1 | 0 | |a Azadeh Aliarab |e author |
| 700 | 1 | 0 | |a Giada Sebastiani |e author |
| 700 | 1 | 0 | |a Kostas Pantopoulos |e author |
| 245 | 0 | 0 | |a Oxidative Stress in Liver Pathophysiology and Disease |
| 260 | |b MDPI AG, |c 2023-08-01T00:00:00Z. | ||
| 500 | |a 10.3390/antiox12091653 | ||
| 500 | |a 2076-3921 | ||
| 520 | |a The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which not only arise during metabolic functions but also during the biotransformation of xenobiotics. The disruption of redox balance causes oxidative stress, which affects liver function, modulates inflammatory pathways and contributes to disease. Thus, oxidative stress is implicated in acute liver injury and in the pathogenesis of prevalent infectious or metabolic chronic liver diseases such as viral hepatitis B or C, alcoholic fatty liver disease, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Moreover, oxidative stress plays a crucial role in liver disease progression to liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Herein, we provide an overview on the effects of oxidative stress on liver pathophysiology and the mechanisms by which oxidative stress promotes liver disease. | ||
| 546 | |a EN | ||
| 690 | |a ROS | ||
| 690 | |a liver disease | ||
| 690 | |a fibrosis | ||
| 690 | |a hepatitis | ||
| 690 | |a NAFLD | ||
| 690 | |a NASH | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antioxidants, Vol 12, Iss 9, p 1653 (2023) | |
| 787 | 0 | |n https://www.mdpi.com/2076-3921/12/9/1653 | |
| 787 | 0 | |n https://doaj.org/toc/2076-3921 | |
| 856 | 4 | 1 | |u https://doaj.org/article/96f861c67ec04be88a02d1f829e76ab3 |z Connect to this object online. |