Chitosan-Integrated Curcumin-Graphene Oxide/Copper Oxide Hybrid Nanocomposites for Antibacterial and Cytotoxicity Applications

• Main Authors: Anandhavelu Sanmugam (Author), Logesh Kumar Sellappan (Author), Abbishek Sridharan (Author), Swathy Manoharan (Author), Ananda Babu Sairam (Author), Abdulrahman I. Almansour (Author), Subha Veerasundaram (Author), Hyun-Seok Kim (Author), Dhanasekaran Vikraman (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

This study deals with the facile synthesis of a single-pot chemical technique for chitosan-curcumin (CUR)-based hybrid nanocomposites with nanostructured graphene oxide (GO) and copper oxide (CuO) as the antibacterial and cytotoxic drugs. The physicochemical properties of synthesized hybrid nanocomposites such as CS-GO, CS-CuO, CS-CUR-GO, and CS-CUR-GO/CuO were confirmed with various advanced tools. Moreover, the in vitro drug release profile of the CS-CUR-GO/CuO nanocomposite exhibited sustained and controlled release during different time intervals. Also, the antibacterial activity of the CS-CUR-GO/CuO hybrid nanocomposite presented the maximum bactericidal effect against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> pathogens. The hybrid nanocomposites revealed improved cytotoxicity behaviour against cultured mouse fibroblast cells (L929) via cell adhesion, DNA damage, and proliferation. Thus, the chitosan-based hybrid nanocomposites offer rich surface area, biocompatibility, high oxidative stress, and bacterial cell disruption functionalities as a potential candidate for antibacterial and cytotoxicity applications.

Item Description

10.3390/antibiotics13070620
2079-6382