Targeting NOX2 and glycolytic metabolism as a therapeutic strategy in acute myeloid leukaemia

• Main Authors: Carla Ijurko (Author), Marta Romo-González (Author), Rodrigo Prieto-Bermejo (Author), María Díez-Campelo (Author), María-Belén Vidriales (Author), Sandra Muntión (Author), Fermín Sánchez-Guijo (Author), Jesús Sánchez-Yagüe (Author), Ángel Hernández-Hernández (Author)
• Format: Bog
• Udgivet: BMC, 2024-10-01T00:00:00Z.
• Fag: article
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Abstract Acute myeloid leukaemia (AML) is a highly heterogeneous malignancy, with a poor 5-year overall survival rate of approximately 30%. Consequently, the search for novel therapeutic strategies is ongoing, and the identification of new vulnerabilities could accelerate progress. Oxidative stress...