Formulation development of itraconazole PEGylated nano-lipid carriers for pulmonary aspergillosis using hot-melt extrusion technology

• Main Authors: Gauri Shadambikar (Author), Sushrut Marathe (Author), Nan Ji (Author), Mashan Almutairi (Author), Suresh Bandari (Author), Feng Zhang (Author), Mahavir Chougule (Author), Michael Repka (Author)
• Formato: Livro
• Publicado em: Elsevier, 2021-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Pulmonary delivery is a promising alternative for the oral treatment of pulmonary aspergillosis. This study aimed to develop continuous and scalable itraconazole PEGylated nano-lipid carriers (ITZ-PEG-NLC) for inhalation delivery. The feasibility of preparing NLCs utilizing hot-melt extrusion (HME)...