Immunogenicity of Inactivated SARS-CoV-2 Vaccines in Patients With Rheumatoid Arthritis: A Case Series

ObjectivesAttenuated humoral response to mRNA SARS-CoV-2 vaccines has been reported in some patients with autoimmune disease, e.g., rheumatoid arthritis (RA). However, data of immune responses to inactivated SARS-CoV-2 vaccine in the RA population are still unknown. Herein, the safety and immunogeni...

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Hauptverfasser: Ting Zhao (VerfasserIn), Jiayan Shen (VerfasserIn), Youyang Zhu (VerfasserIn), Xiaofang Tian (VerfasserIn), Guangfen Wen (VerfasserIn), Yuanyuan Wei (VerfasserIn), Bonan Xu (VerfasserIn), Chenyang Fu (VerfasserIn), Zhaohu Xie (VerfasserIn), Yujiang Xi (VerfasserIn), Zhenmin Li (VerfasserIn), Jiangyun Peng (VerfasserIn), Yang Wu (VerfasserIn), Xiaohu Tang (VerfasserIn), Chunping Wan (VerfasserIn), Lei Pan (VerfasserIn), Zhaofu Li (VerfasserIn), Dongdong Qin (VerfasserIn)
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Veröffentlicht: Frontiers Media S.A., 2022-04-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Ting Zhao  |e author 
700 1 0 |a Ting Zhao  |e author 
700 1 0 |a Jiayan Shen  |e author 
700 1 0 |a Jiayan Shen  |e author 
700 1 0 |a Youyang Zhu  |e author 
700 1 0 |a Xiaofang Tian  |e author 
700 1 0 |a Guangfen Wen  |e author 
700 1 0 |a Yuanyuan Wei  |e author 
700 1 0 |a Bonan Xu  |e author 
700 1 0 |a Chenyang Fu  |e author 
700 1 0 |a Zhaohu Xie  |e author 
700 1 0 |a Yujiang Xi  |e author 
700 1 0 |a Zhenmin Li  |e author 
700 1 0 |a Jiangyun Peng  |e author 
700 1 0 |a Yang Wu  |e author 
700 1 0 |a Xiaohu Tang  |e author 
700 1 0 |a Chunping Wan  |e author 
700 1 0 |a Lei Pan  |e author 
700 1 0 |a Zhaofu Li  |e author 
700 1 0 |a Dongdong Qin  |e author 
245 0 0 |a Immunogenicity of Inactivated SARS-CoV-2 Vaccines in Patients With Rheumatoid Arthritis: A Case Series 
260 |b Frontiers Media S.A.,   |c 2022-04-01T00:00:00Z. 
500 |a 2296-2565 
500 |a 10.3389/fpubh.2022.875558 
520 |a ObjectivesAttenuated humoral response to mRNA SARS-CoV-2 vaccines has been reported in some patients with autoimmune disease, e.g., rheumatoid arthritis (RA). However, data of immune responses to inactivated SARS-CoV-2 vaccine in the RA population are still unknown. Herein, the safety and immunogenicity of inactivated SARS-CoV-2 vaccines in RA patients were analyzed.MethodsSeventy five RA patients and 26 healthy controls (HC) were respectively recruited from Yunnan Provincial Hospital of Traditional Chinese Medicine and the community in Kunming city. Neutralizing Antibody (NAb) Test ELISA kit was used to measure the percentage of inhibition. AKA (anti-keratin antibody) positivity was detected using indirect immunofluorescence. Rheumatoid factor (RF)-IgA was detected by ELISA. RF-IgG, RF-IgM, and anti-cyclic citrullinated peptide (CCP) antibodies were measured by chemiluminescence. ESR (erythrocyte sedimentation rate) was detected by ESR analyzer. C-RP (c-reactive protein) was detected by immunoturbidimetry. NEUT% (percentage of neutrophils) and LYMPH% (percentage of percentage) were calculated by a calculation method.ResultsCompared with the HC group, the percentage of inhibition was significantly lower in RA patients receiving two doses of vaccines. Vaccines-induced percentage of inhibition was the lowest in RA patients who had not been vaccinated. In total 80.77% of the HC group had a percentage of inhibition ≧20%, compared with 45.24% of vaccinated RA patients and 6.06% of unvaccinated RA patients. Spearman correlation analysis revealed that antibody responses to SARS-CoV-2 did not differ between RA patients according to their age and disease duration. Furthermore, the results showed that no correlation was found between the percentage of inhibition and indices for RA, including RF-IgA, IgG, IgM; anti-CCP antibody; ESR; C-RP; NEUT% and LYMPH%.ConclusionOur study showed inactivated vaccine-induced SARS-COV-2 antibody responses differ in RA patients and healthy subjects, emphasizing the importance of a third or fourth vaccination in RA patients. 
546 |a EN 
690 |a COVID-19 
690 |a inactivated SARS-CoV-2 vaccines 
690 |a rheumatoid arthritis 
690 |a neutralizing antibodies 
690 |a immunogenicity 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Frontiers in Public Health, Vol 10 (2022) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fpubh.2022.875558/full 
787 0 |n https://doaj.org/toc/2296-2565 
856 4 1 |u https://doaj.org/article/9771f36dfebb470eb8c51f6064daffa7  |z Connect to this object online.