Protective Action of Indapamide, a Thiazide-Like Diuretic, on Ischemia-Induced Injury and Barrier Dysfunction in Mouse Brain Microvascular Endothelial Cells

• Main Authors: Tsuyoshi Nishioku (Author), Fuyuko Takata (Author), Atsushi Yamauchi (Author), Noriko Sumi (Author), Ikumi Yamamoto (Author), Akiko Fujino (Author), Mikihiko Naito (Author), Takashi Tsuruo (Author), Hideki Shuto (Author), Yasufumi Kataoka (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the present study was to elucidate the effects of indapamide on ischemic damage to the blood-brain barrier (BBB) in vitro. The ischemia /reperfusion conditions employed here significantly decreased the viability of mouse brain capillary endothelial (MBEC4) cells, an effect ameliorated by...