Population Pharmacokinetic Characteristics of Amikacin in Suspected Cases of Neonatal Sepsis in a Low-Resource African Setting: A Prospective Nonrandomized Single-Site Study

• Main Authors: Seth K. Amponsah, PhD (Author), George O. Adjei, MD, PhD (Author), Christabel Enweronu-Laryea, MRCPCH (Author), Kwasi A. Bugyei, PhD (Author), Kosta Hadji-Popovski, MSc Pharm (Author), Jorgen A.L. Kurtzhals, MD, PhD (Author), Kim Kristensen, PhD (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Amikacin exhibits marked pharmacokinetic (PK) variability and is commonly used in combination with other drugs in the treatment of neonatal sepsis. There is a paucity of amikacin PK information in neonates from low-resource settings. Objectives: To determine the PK parameters of amikacin...