Lack of Evidence for Involvement of P-Glycoprotein in Brain Uptake of the Centrally Acting Analgesic, Tramadol in the Rat
Purpose. Tramadol Hydrochloride is a widely-used centrally acting analgesic drug, which has some features of being a P-gp substrate. The present study evaluates the functional involvement of P-gp in CNS distribution of tramadol. Methods. The possibe involvement of P-glycoprotein in brain distributio...
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| Main Authors: | , , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2012-11-01T00:00:00Z.
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