Analysis of clinical characteristics of 36 cases of extramammary Paget's disease

• Main Authors: Meng-lian LI (Author), Di CAO (Author), Yun PAN (Author), Ai-jun CHEN (Author)
• Format: Book
• Published: editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Objective: To evaluate the clinical features of extramammary Paget's disease by retrospectively studying cases. Methods: Statistical analyses were performed on the clinical data of 36 cases of extramammary Paget's disease from January 2013 to December 2018. Results: Extramammary Paget's disease usually occurred in males with a ratio of 3 ∶1.The average age of onset was (65.72±10.41) years and the course of disease ranged from 6 months to 10 years with a mean of 4 years. Single lesions accounted for the majority, and the most common site was the scrotum. The main lesions were erythema and erosion. 60.61% of the patients were misdiagnosed. Immunohistochemistry showed mainly positive for CK7, CEA and EMA.30 cases had no metastasis while 6 cases did.30 patients underwent extended local excision and intraoperative frozen section, and 2 out of them relapsed. Among the 30 surgical cases, 27 patients had a clear resection range most of which were about 1.0 cm and 2.0 cm. The extended resection of 2.0 cm had a relatively higher one-time total excision rate of 90.91%. Conclusions: Extramammary Paget's disease is more common in males and the elders with a high rate of misdiagnosis. Most of the EMPD lesions are single. Primary or secondary can be distinguished by immunohistochemistry. With a slow progression, extramammary Paget's disease can still metastasize. Extended local excision and intraoperative frozen section is the main treatment and 2.0 cm is suggested as the extended resection.

Item Description

1674-8468
10.3969/j.issn.1674-8468.2020.02.006