Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions

• Main Authors: Yuki Minayoshi (Author), Hitoshi Maeda (Author), Hiroki Yanagisawa (Author), Keisuke Hamasaki (Author), Yuki Mizuta (Author), Kento Nishida (Author), Ryo Kinoshita (Author), Yuki Enoki (Author), Tadasi Imafuku (Author), Victor Tuan Giam Chuang (Author), Tomoaki Koga (Author), Yukio Fujiwara (Author), Motohiro Takeya (Author), Kayoko Sonoda (Author), Tomohiko Wakayama (Author), Kazuaki Taguchi (Author), Yu Ishima (Author), Tatsuhiro Ishida (Author), Yasuko Iwakiri (Author), Motohiko Tanaka (Author), Yutaka Sasaki (Author), Hiroshi Watanabe (Author), Masaki Otagiri (Author), Toru Maruyama (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Because of its multifaceted anti-inflammatory and immunomodulatory effects, delivering type-I interferon to Kupffer cells has the potential to function as a novel type of therapy for the treatment of various types of hepatitis. We report herein on the preparation of a Kupffer cell targeting type-I i...